Won Gyeong (Cha Joo Young), a daughter of the prestigious Min family, is intelligent and ambitious. She marries Yi Bang Won (Lee Hyun Wook), the fifth son of King Tae Jo, who aspires to ascend the throne. However, his father designates his second son as the next king instead, spurring Won Gyeong and Bang Won to make alternate plans. Won Gyeong successfully becomes a "King Maker" by helping Bang Won become the third King of Joseon, establishing a new regime together. After Bang Won becomes the king, however, he continuously betrays their family and her love by taking in more concubines. Nevertheless, Won Gyeong will not be swayed from her desire to change the world. This drama was based on the true historical regime of Queen Won Gyeong and King Tae Jong of Joseon.

Hyeong Ju is a violent crime detective who lives a contented and fulfilling life but is given the mysterious opportunity to go back in time. Ga Hyeon is a famous webcomic author known for her mystery thriller stories. Unfortunately, a workaholic and perfectionist, Ga Hyeon, suffers from a terrible accident and receives the same offer to go back in time. In addition to 8 other individuals, the two of them reset their lives for the better but quickly begin to uncover a series of mysterious events that threaten their future.

In order to live, a woman named Eun Han risks her life by going through a dangerous surgical procedure for a new face. However, due to the after-effects of surgery, she loses her memory. She tries to find the missing pieces of her memory and while suffering from a different face and not knowing about herself, Kang Woo appears in front of her. Kang Woo has been hurt as his lover left him. He suffers as his relationship with his father gets worse. Like they were destined, Eun Han and Kang Woo reunites. He becomes determined to help Eun Han find her memory. As they work together, Kang Woo slowly opens up his closed heart to Eun Han. Meanwhile, Chan Ki, the morning news anchor, lives a perfect life. However, he seems to have a dark side which no one would have ever imagined. This mystery melodrama takes people to unexpected places with unexpected people.